Peptic activity after the administration of Pentagastrin and in gastroduodenal disease.

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Peptic activity after the administration of Pentagastrin and in gastroduodenal disease.

The existence of more than one gastric pepsin has been reported by many authors. Herriott, Desreux, and Northrop (1940) separated two proteolytic fractions from human gastric juice by salt-fractionation methods, and similar results were described by Baker (1951) and Taylor (1959b). Using moving boundary electrophoresis, Kushner, Rapp, and Burtin (1964), Merten, Schramm, Grassmann, and Hannig (1...

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Peptic activity and gastroduodenal mucosal damage.

This contribution reviews briefly the history of the discovery and characterization of peptic activity; secretory models and current concepts regarding the regulation of pepsinogen secretion; and evidence that pepsin is a necessary co-factor for gastroduodenal mucosal injury. Several animal studies indicate that peptic activity is required for acid- and nonsteroidal anti-inflammatory drug-induc...

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ژورنال

عنوان ژورنال: Gut

سال: 1969

ISSN: 0017-5749

DOI: 10.1136/gut.10.4.303